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Research For Glioblastoma Multiforme

Glioblastoma Multiforme

TCGA researchers have identified a new subtype of GBM that affects younger adults and has an increased survival rate. A subset of GBM tumors had specific chemical changes or ‘marks’ called methylation of a large group of genes. The methylation of these genes may account for the improved survival of these patients when compared to patients with other subtypes of GBM. These findings could aid in development of new treatment options for these patients.

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New Gene Changes and Signaling Pathways

The findings validated TCGA’s approach by confirming previously discovered GBM gene mutations and uncovering new mutations in these genes. For example, scientists have known that mutations in the NF1 gene are involved in GBM’s development, but they have been unsure how important a role they play.

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Four Distinct Subtypes of Glioblastoma

Using its previously published description of genomic changes that drive glioblastoma (GBM) tumor development, The Cancer Genome Atlas (TCGA) researchers have now established the existence of four subtypes of GBM.

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Genomics and Biology of Glioblastoma

The National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI) held a workshop entitled, “Genomics and Biology of Glioblastoma Multiforme (GBM),” to review the initial GBM data from the TCGA pilot project.

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Clinical Findings On Glioblastoma

Stephen Baylin, M.D., discusses the potential clinical implications from decoding the brain cancer genome in a combined effort with The Cancer Genome Atlas at the National Cancer Institute

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Findings on Subtypes of Glioblastoma

New findings by researchers at UNC Lineberger Comprehensive Cancer Center suggest that the most common form of malignant brain cancer in adults, glioblastoma multiforme (GBM), is probably not a single disease but a set of diseases, each with a distinct underlying molecular disease process. The study was published by Cell Press in the January issue of the journal Cancer Cell and the researchers are part of the The Cancer Genome Atlas.

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Identifying Important Gene Alterations

Cancer genomics researchers are exploring new ways to sort through the mountains of TCGA-generated data on gene changes from cancers like glioblastoma multiforme (GBM). GBM is a lethal adult brain cancer with mean survival time of little more than a year.

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Comprehensive View of GBM Genome

Scientists from the University of Helsinki in Finland1 have developed a computer program called Anduril that combines, organizes and analyzes the massive amounts of data generated from The Cancer Genome Atlas (TCGA). To demonstrate the system’s features, they used TCGA’s genomic data on glioblastoma multiforme (GBM), the most common adult brain tumor.

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Discovery of a Gene Pathway Interaction

Cancer genomics researchers are increasingly using TCGA data to develop and test hypotheses about how cancer develops. TCGA’s recently completed glioblastoma multiforme (GBM) dataset of gene changes has informed several recent studies, including one from Harvard and Northwestern researchers in the September 2010 issue of Genes and Development.

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